Characterization of Heterotopic and Orthotopic Syngeneic MOC1 and MOC2 Tumor Models

MOC1 and MOC2 represent two human papillomavirus (HPV)-negative mouse oral carcinoma (MOC) models commonly used for preclinical studies of head and neck squamous cell carcinoma (HNSCC). While most publications employ subcutaneous heterotopic implantation of these cell lines, orthotopic models are increasingly being used to better recapitulate the tumor microenvironment of human HNSCC. However, the behavior of these tumor models based on location has not been well characterized. Here we present a comparison of time to tumor onset, tumor penetrance, and metastatic potential for MOC1 and MOC2 tumor models in heterotopic (subcutaneous vs intramuscular) or orthotopic (buccal) locations.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 217 Source Type: research