Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver

CONCLUSIONS: A highly efficient and liver-specific BAC-Alb-FlpO mouse model was developed. In combination with other Cre lines, different genes can be manipulated sequentially in the same cell, or distinct genetic changes can be induced in different cell types of the same organism.PMID:38469630 | DOI:10.1152/ajpgi.00263.2023

Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Xiaohui Zhu Yan Yang Dongfeng Feng Oliver Wang Jiaxiang Chen Jiale Wang Bin Wang Yang Liu Brandy H Edenfield Ashley N Haddock Ying Wang Tushar Patel Yan Bi Baoan Ji Source Type: research