Epilepsy-related functional brain network alterations are already present at an early age in the GAERS rat model of genetic absence epilepsy

Discussionrs-fMRI, MEMRI, and volumetric data collectively suggest the significance of cortical networks in GAERS, which correlates with an increased fronto-central connectivity in childhood absence epilepsy (CAE). Our findings also verify involvement of basal ganglia and limbic regions. Epilepsy-related network alterations are already present in juvenile animals. Consequently, this early condition seems to play a greater role in dynamic brain function than chronic absence seizures.
Source: Frontiers in Neurology - Category: Neurology Source Type: research