Gene expression profiling on CML patients with Philadelphia translocation
CONCLUSIONS: The results demonstrate a correlation between signaling pathways and the development of treatment resistance in patients with CML. These pathways exhibited enhanced efficacy in transmitting signals downstream of the TKI target, BCR-ABL. Several target genes require additional validation in a more extensive cohort study to verify their correlation with TKI resistance. The present research highlights that many BCR-ABL-independent pathways may be correlated with resistance, thus enhancing the prospective therapy options for patients with CML.PMID:38436167 | DOI:10.26355/eurrev_202402_35455
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Authors: H Alkhatabi S Aldahlawi M S Hazzazi R Alsolami A Elaimi M N Almashjary R Alserihi H A Alkhatabi M E Alquthami Y M Daous S Bahashwan E B Yasin A Barefah F Alsayes Source Type: research
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