Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen

CONCLUSIONS: These results suggest that the increased expression of COLVI in DS may result in lower migration-driven elongation of endocardial cushions stemming from lower cell proliferation and migration, possibly contributing to the high incidence of CHD in the DS population.SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12195-023-00791-x.PMID:38435791 | PMC:PMC10901762 | DOI:10.1007/s12195-023-00791-x

Source: Molecular Medicine - March 4, 2024 Category: Molecular Biology Authors: Rachel S Reeser Alyssa K Salazar Kendra M Prutton James R Roede Mitchell C VeDepo Jeffrey G Jacot Source Type: research