Gene expression profiling on CML patients with Philadelphia translocation

CONCLUSIONS: The results demonstrate a correlation between signaling pathways and the development of treatment resistance in patients with CML. These pathways exhibited enhanced efficacy in transmitting signals downstream of the TKI target, BCR-ABL. Several target genes require additional validation in a more extensive cohort study to verify their correlation with TKI resistance. The present research highlights that many BCR-ABL-independent pathways may be correlated with resistance, thus enhancing the prospective therapy options for patients with CML.PMID:38436167 | DOI:10.26355/eurrev_202402_35455

Source: European Review for Medical and Pharmacological Sciences - March 4, 2024 Category: Drugs & Pharmacology Authors: H Alkhatabi S Aldahlawi M S Hazzazi R Alsolami A Elaimi M N Almashjary R Alserihi H A Alkhatabi M E Alquthami Y M Daous S Bahashwan E B Yasin A Barefah F Alsayes Source Type: research