The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects

CONCLUSION: Fentanyl administration induced neurotoxic effects in the mouse cerebral cortex that could be primarily mediated by the evoked oxidative-inflammatory response. The altered expression of NMDA receptors, dopamine receptors, and EGF suggests the pernicious effects of fentanyl addiction that may end in the development of toxic psychosis.PMID:38428507 | DOI:10.1016/j.brainresbull.2024.110917

Source: Brain Research Bulletin - March 1, 2024 Category: Neurology Authors: Ayman Alzu'bi Worood Bani Baker Bahaa Al-Trad Mazhar Salim Al Zoubi Manal Isam AbuAlArjah Ejlal Abu-El-Rub Lena Tahat Ahmed Mnz Helaly Doaa S Ghorab Waseem El-Huneidi Raed M Al-Zoubi Source Type: research