Evaluation of the risk factors for the failure of a single prophylactic dose of anticholinergic drugs for irinotecan-induced cholinergic symptoms

CONCLUSION: We determined that colorectal cancer, female sex, and prophylactic use of scopolamine butyl bromide were risk factors associated with the failure of a single prophylactic dose of anticholinergic drugs, and that multiple prophylactic doses for wearing-off can be a promising method.PMID:38431832 | DOI:10.5414/CP204531

Source: International Journal of Clinical Pharmacology and Therapeutics - March 3, 2024 Category: Drugs & Pharmacology Authors: Takuya Watanabe Yoshitaka Saito Yoh Takekuma Yasushi Shimizu Ichiro Kinoshita Yoshito Komatsu Mitsuru Sugawara Source Type: research