Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling
The regenerative capacity of the adult mammalian heart is limited, while the neonatal heart is an organ with regenerative and proliferative ability. Activating adult cardiomyocytes (CMs) to re-enter the cell cycle is an effective therapeutic method for ischemic heart disease such as myocardial infarction (MI) and heart failure. Here, we aimed to reveal the role and potential mechanisms of cellular nucleic acid binding protein (CNBP) in cardiac regeneration and repair after heart injury. CNBP is highly expressed within 7  days post-birth while decreases significantly with the loss of regenerative ability.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Chong Du, Shan Zhao, Tiankai Shan, Xudong Han, Qiqi Jiang, Jiawen Chen, Lingfeng Gu, Tianwen Wei, Tongtong Yang, Sibo Wang, Hao Wang, Xuejiang Guo, Liansheng Wang Source Type: research
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