Ferroptosis: Biology and Role in Gastrointestinal Disease

Ferroptosis is a form of nonapoptotic cell death that involves iron-dependent phospholipid peroxidation induced by accumulation of reactive oxygen species (ROS), and results in plasma membrane damage and the release of damage-associated molecular patterns. Ferroptosis has been implicated in aging and immunity, as well as disease states including intestinal and liver conditions and cancer. To date, several ferroptosis-associated genes and pathways have been implicated in liver disease. While ferroptotic cell death is associated with dysfunction of the intestinal epithelium, the underlying molecular basis is poorly understood.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research