Treatment Response Prediction in Major Depressive Disorder Using Multimodal MRI and Clinical Data: Secondary Analysis of a Randomized Clinical Trial

CONCLUSIONS: The study results confirm that early sertraline treatment response can be predicted; that the models are sertraline specific compared with placebo; that prediction benefits from integrating multimodal MRI data with clinical data; and that perfusion imaging contributes most to these predictions. Using this approach, a lean and effective protocol could individualize sertraline treatment planning to improve psychiatric care.PMID:38321916 | DOI:10.1176/appi.ajp.20230206

Source: The American Journal of Psychiatry - February 7, 2024 Category: Psychiatry Authors: Maarten G Poirot Henricus G Ruhe Henk-Jan M M Mutsaerts Ivan I Maximov Inge R Groote Atle Bj ørnerud Henk A Marquering Liesbeth Reneman Matthan W A Caan Source Type: research