Causal association between lipoproteins and risk of coronary artery disease —a systematic review and meta-analysis of Mendelian randomization studies

ConclusionThe present meta-analysis suggests an overall effect of causal association between lipoproteins and CAD. Most of the non-HDL lipoproteins (LDL, apoB, Lp(a)) promote CAD, while the protective effect of HDL in CAD still needs to be verified in the future.Graphical abstract• The roles of lipoproteins in the development of CAD have been raised due to various reasons, and no systemic review has analyzed data from MR studies yet.• This study included a total of 5,828,409 participates from 21 records with quality and bias assessed.• The present meta-analysis suggests a overall effect of causal association between lipoproteins and CAD. Most of the non-HDL lipoproteins (LDL, apoB, Lp(a)) promotes CAD, while the protective effect of HDL in CAD still need to be verified in future.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research