Therapeutic Potential of Cornus Genus: Navigating Phytochemistry, Pharmacology, Clinical Studies, and Advanced Delivery Approaches

Chem Biodivers. 2024 Feb 25:e202301888. doi: 10.1002/cbdv.202301888. Online ahead of print.ABSTRACTThe genus Cornus (Cornaceae) plants are widely distributed in Europe, southwest Asia, North America, and the mountains of Central America, South America, and East Africa. Cornus plants exhibit antimicrobial, antioxidative, antiproliferative, cytotoxic, antidiabetic, anti-inflammatory, neuroprotective and immunomodulatory activities. These plants are exploited to possess various phytoconstituents such as triterpenoids, iridoids, anthocyanins, tannins and flavonoids. Pharmacological research and clinical investigations on various Cornus species have advanced significantly in recent years. Over the past few decades, a significant amount of focus has also been made into developing new delivery systems for Cornus mas and Cornus officinalis. This review focuses on the morphological traits, ethnopharmacology, phytochemistry, pharmacological activities and clinical studies on extracts and active constituents from plants of Cornus genus. The review also highlights recent novel delivery systems for Cornus mas and Cornus officinalis extracts to promote sustained and targeted delivery in diverse disorders. The overwhelming body of research supports the idea that plants from the genus Cornus have therapeutic potential and can be investigated in the future for treatingseveral ailments.PMID:38403786 | DOI:10.1002/cbdv.202301888

Source: Chemistry and Biodiversity - February 25, 2024 Category: Biochemistry Authors: Subhashini Badoni Deepshikha Rawat Arun Kumar Mahato Nitish Singh Jangwan Ghulam Md Ashraf Athanasios Alexiou Haythum O Tayeb Badrah S Alghamdi Marios Papadakis Mamta F Singh Source Type: research