The potential therapeutic effect of melatonin in oxaliplatin combination therapy against chemoresistant colorectal cancer cells

CONCLUSIONS: The results of cytotoxicity assays, MTT, and flow cytometry revealed that the combination of melatonin and oxaliplatin exerts synergistic effects on induction of oxaliplatin's cytotoxicity in CRC. Our research suggests that combining the treatments of melatonin and oxaliplatin may be considered as a new approach to overcoming oxaliplatin resistance in CRC patients.PMID:38401018 | DOI:10.1007/s11033-024-09316-9

Source: Mol Biol Cell - February 24, 2024 Category: Molecular Biology Authors: Masoumeh Dehghanzad Mohammad Mohammadi Mohaddeseh Nejati Farhad Pouremamali Nazila Fathi Maroufi Maryam Akbarzadeh Naser Samadi Mohammad Nouri Source Type: research