< em > ANGPTL3 < /em > Downregulation Increases Intracellular Lipids by Reducing Energy Utilization

CONCLUSIONS: In conclusion, intracellular ANGPTL3 downregulation by silencing RNA led to an increase in triglycerides content due to a reduction in energy substrate utilization resembling a primary intracellular hepatocyte hypothyroidism.PMID:38385290 | DOI:10.1161/ATVBAHA.123.319789

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Grazia Pennisi Samantha Maurotti Ester Ciociola Oveis Jamialahmadi Giorgio Bertolazzi Angela Mirarchi Per-Olof Bergh Francesca Scionti Rosellina M Mancina Rocco Spagnuolo Claudio Tripodo Jan Boren Salvatore Petta Stefano Romeo Source Type: research