High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis

CONCLUSIONS: Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.PMID:38385291 | DOI:10.1161/ATVBAHA.123.320524

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Alexander C Bashore Hanying Yan Chenyi Xue Lucie Y Zhu Eunyoung Kim Thomas Mawson Johana Coronel Allen Chung Nadja Sachs Sebastian Ho Leila S Ross Michael Kissner Emmanuelle Passegu é Robert C Bauer Lars Maegdefessel Mingyao Li Muredach P Reilly Source Type: research