9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models

In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.PMID:38381472 | DOI:10.1016/j.neurobiolaging.2023.09.005

Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Rachel Twitto-Greenberg Sigal Liraz-Zaltsman Daniel M Michaelson Ori Liraz Irit Lubitz Dana Atrakchi-Baranes Chen Shemesh Uri Ashery Itzik Cooper Ayelet Harari Dror Harats Michal Schnaider-Beeri Aviv Shaish Source Type: research