Genes, Vol. 15, Pages 276: Genetic Risk Factors and Clinical Outcomes in Childhood Eye Cancers: A Review
Genes, Vol. 15, Pages 276: Genetic Risk Factors and Clinical Outcomes in Childhood Eye Cancers: A Review
Genes doi: 10.3390/genes15030276
Authors:
Syed Hameed
Angeli Christy Yu
Bashaer Almadani
Shereen Abualkhair
Khabir Ahmad
Giorgio Zauli
Childhood eye cancers, although rare, present substantial health challenges, affecting the pediatric population with a remarkable impact on their lives and families. This comprehensive review provides insights into the various types of ocular tumors, primarily focusing on malignant eye tumors, their genetic predispositions, and advancements in managing these conditions. Understanding the genetic risk factors is crucial for early detection, risk assessment, and the development of targeted therapies. This review discusses genome-wide association (GWAS) and next-generation sequencing (NGS) studies to find common and rare genetic variants. Furthermore, it also explores the outcomes and implications of these genetic discoveries in treating pediatric ocular cancer. These findings underscore the significance of genetic research in guiding early interventions and improving outcomes in children with ocular cancers.
Source: Genes - Category: Genetics & Stem Cells Authors: Syed Hameed Angeli Christy Yu Bashaer Almadani Shereen Abualkhair Khabir Ahmad Giorgio Zauli Tags: Review Source Type: research
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