Genes, Vol. 15, Pages 272: Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies
Genes, Vol. 15, Pages 272: Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies
Genes doi: 10.3390/genes15030272
Authors:
Natasha Delphin
Caitlin Aust
Lyn Griffiths
Francesca Fernandez
Despite extensive research over the last few decades, the etiology of schizophrenia (SZ) remains unclear. SZ is a pathological disorder that is highly debilitating and deeply affects the lifestyle and minds of those affected. Several factors (one or in combination) have been reported as contributors to SZ pathogenesis, including neurodevelopmental, environmental, genetic and epigenetic factors. Deoxyribonucleic acid (DNA) methylation and post-translational modification (PTM) of histone proteins are potentially contributing epigenetic processes involved in transcriptional activity, chromatin folding, cell division and apoptotic processes, and DNA damage and repair. After establishing a summary of epigenetic processes in the context of schizophrenia, this review aims to highlight the current understanding of the role of DNA methylation and histone PTMs in this disorder and their potential roles in schizophrenia pathophysiology and pathogenesis.
Source: Genes - Category: Genetics & Stem Cells Authors: Natasha Delphin Caitlin Aust Lyn Griffiths Francesca Fernandez Tags: Review Source Type: research
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