Hepatic Encephalopathy

Hepatic encephalopathy (HE) is an extremely debilitating complication of liver cirrhosis. The basis for the development of HE stems from the interaction of dysbiosis, sarcopenia, liver insufficiency, and portal hypertension.1 Precipitants of HE include electrolyte disturbances, renal insufficiency, constipation, infection, gastrointestinal bleeding, and use of select medications. Hepatic encephalopathy is rather unique among other manifestations of liver failure in that it affects not only patients but also their caregivers; leaves a cognitive footprint that can persist even after liver transplantation; is a hallmark that marks the beginning of increased health care utilization; and, in severe cases, can be associated with decreased survival.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Tags: Preface Source Type: research