DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum

Voriconazole is a triazole antifungal agent used to treat intractable fungal infections [1]. However, voriconazole may cause photosensitivity as a side effect [1,2]. Voriconazole-induced photosensitivity causes erythema, hyperpigmentation, and skin tumors at sun-exposed sites. These symptoms are similar to those observed in patients with xeroderma pigmentosum (XP), who are susceptible to developing skin cancers and accelerated freckle-like pigmented maculae owing to impaired DNA lesion repair caused by ultraviolet radiation (UV) exposure [3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research