Dual-hit strategy for therapeutic targeting of pancreatic cancer in patient-derived xenograft tumors

CONCLUSION: This dual-hit strategy of SMO and FGFR inhibition provides a clinically-translatable approach to compromise the profound impermeability of PDAC tumors. Furthermore, clinical deployment of DW-MR imaging could fulfill the essential clinical-translational requirement for patient stratification.PMID:38270582 | DOI:10.1158/1078-0432.CCR-23-0131

Source: Clinical Cancer Research - January 25, 2024 Category: Cancer & Oncology Authors: Tista Roy Chaudhuri Qingxiang Lin Ewa K Stachowiak Spencer R Rosario Joseph A Spernyak Wen Wee Ma Michal K Stachowiak Michelle K Greene Gerard P Quinn Simon S McDade Martin Clynes Christopher J Scott Robert M Straubinger Source Type: research