Epigenetic silencing < em > ZSCAN23 < /em > promotes pancreatic cancer growth by activating Wnt signaling

In this study, we explored the epigenetic regulation and the function of ZSCAN23 in PDAC. ZSCAN23 was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of ZSCAN23 inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. ZSCAN23 suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, ZSCAN23 inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. ZSCAN23 is frequently methylated in PDAC and may serve as a detective marker. ZSCAN23 suppresses PDAC cell growth both in vitro and in vivo.PMID:38226836 | PMC:PMC10793710 | DOI:10.1080/15384047.2024.2302924
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research