Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy

In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral neuropathy and its underlying mechanisms were investigated. The diabetic peripheral neuropathy rat model was established by using a high-fat diet combined with streptozotocin injection, and experimental subjects were divided into normal, diabetic peripheral neuropathy, and alirocumab groups. The results showed that Alirocumab improved nerve conduction, morphological changes, and small fiber deficits in rats with DPN, possibly related to its amelioration of oxidative stress and the inflammatory response.PMID:38233122 | DOI:10.1507/endocrj.EJ23-0359

Source: Endocrine Journal - January 17, 2024 Category: Endocrinology Authors: Na Cui Yonghao Feng Ming Wang Xiuyan Lu Yongmei Huang Yinghui Chen Xiaohong Shi Source Type: research