Validation of genes for H-ARS severity prediction in leukemia patients - interspecies comparison, challenges, and promises

CONCLUSION: Identified genes for H-ARS severity prediction, previously detected in baboons, were validated in ALL but not in AML patients. Limitations related to leukemia type, associated reduced RNA amounts, suppressed GE changes, and methodological challenges must be considered as factors negatively affecting the total number of validated genes. Based on that, we propose additional controls including blood cell counts and preferably fluorescence-based RNA quantity measurements for selecting promising samples and using a more sensitive 96-well format for candidate genes with low baseline copy numbers.PMID:38227483 | DOI:10.1080/09553002.2023.2295295

Source: International Journal of Radiation Biology - January 16, 2024 Category: Radiology Authors: Daniel Schwanke Marco Valente Patrick Ostheim Simone Sch üle Laure Bobyk Michel Drouet Diane Riccobono Nicolas Magn é Elisabeth Daguenet Samantha Jo Stewart Razan Muhtadi Matthias Port Michael Abend Source Type: research