Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia

CONCLUSION: We found global HPTM alterations consistent with an aberrantly permissive epigenome in schizophrenia. Further studies to elucidate the significance of enhanced permissive HPTMs in schizophrenia and its association with the mechanism of action of antipsychotic drugs are encouraged.PMID:38302137 | PMC:PMC10843339 | DOI:10.1503/jpn.230054

Source: Journal of Psychiatry and Neuroscience - February 1, 2024 Category: Psychiatry Authors: Oihane Mart ínez-Peula Benito Morentin Luis F Callado J Javier Meana Guadalupe Rivero Alfredo Ramos-Miguel Source Type: research