High molecular/low acetylated chitosans reduce adhesion of Campylobacter jejuni to host cells by blocking JlpA

In conclusion, our data indicate promising antiadhesive and anti-invasive potential of high molecular weight, strongly de-acetylated chitosans for reducing C. jejuni load in livestock and food production. KEY POINTS: • Antiadhesive effects of chitosan with high DP/low DA against C. jejuni to host cells • Specific targeting of JlpA/Hsp90α interaction by chitosan • Meat treatment with chitosan reduces C. jejuni load.PMID:38265503 | PMC:PMC10810038 | DOI:10.1007/s00253-024-13000-0

Source: Applied Microbiology and Biotechnology - January 24, 2024 Category: Microbiology Authors: Vanessa Kreling Franco H Falcone Fabian Herrmann Leon Kemper Daniel Amiteye Stefan Cord-Landwehr Corinna Kehrenberg Bruno M Moerschbacher Andreas Hensel Source Type: research