Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function

CONCLUSION: Loss of EpC through either hyponatremia or mannitol alone results in slowed or disrupted conduction in a genetic model of Nav1.5 LOF. However, combination of these interventions attenuates conduction slowing.PMID:38214908 | DOI:10.1152/ajpheart.00211.2023

Source: American Journal of Physiology. Heart and Circulatory Physiology - January 12, 2024 Category: Physiology Authors: Grace A Blair Xiaobo Wu Chandra Bain Mark Warren Gregory S Hoeker Steven Poelzing Source Type: research