Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy

CONCLUSIONS: N-Demethylation and N-oxygenation were the primary metabolic pathways of sinomenine. This study provides new insight into the in vitro metabolism of sinomenine, which would help prospects of sinomenine disposition and safety assessments.PMID:38211350 | DOI:10.1002/rcm.9669
Source: Rapid Communications in Mass Spectrometry : RCM - Category: Chemistry Authors: Source Type: research