Neurodevelopmental outcomes of preterm and growth-restricted neonate with congenital heart defect: a systematic review and meta-analysis

Conclusions: Based on a low level of evidence, prematurity and/or growth retardation appear to accentuate specific neurodevelopmental outcomes in certain CHD subgroups. Further evidence is needed to confirm these findings.Trial registration: PROSPERO [CRD42020201414].What is Known:• Children born with CHD, preterm birth, or growth restriction at birth are independently at higher risk for neurodevelopmental impairment.• The additional effect of preterm birth and/or growth restriction on neurodevelopmental outcomes in children with CHD remains unclear.What is New:• Prematurity and/or growth retardation appear to accentuate specific neurodevelopmental outcomes in certain CHD subgroups.• Children with CHD, particularly those born preterm or with growth restriction, should undergo lifelong systematic comprehensive neurodevelopmental assessment.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research