Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
ConclusionsHence, high unbound drug intracellular and extracellular exposure at target sites, driven by an interplay of drug transport across the endothelial and parenchymal cellular barriers, is a predisposing factor to CIPN development for CIPN-positive drugs. Critical drug-specific features of unbound drug disposition at various CIPN- sites provide invaluable insights into understanding the pharmacological/toxicological effects at the target-sites which will inform new strategies for monitoring and treatment of CIPN.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
More News: Brain | Chemotherapy | Methotrexate | Neurology | Neuroscience | Nilotinib | Peripheral Neuropathy | Tasigna | Toxicology