Is salivary uric acid, a putative biomarker of pre-eclampsia, of maternal, placental, or fetal origin?

Pre-eclampsia (PE), and fetal growth restriction (FGR), are severe complications of pregnancy, and leading causes of maternal and fetal morbidity and mortality [1]. Pre-eclampsia is defined as de novo onset of hypertension after 20 gestational weeks combined with either proteinuria, organ dysfunction, or FGR [2], while FGR, defined as a fetus not meeting its genetic growth potential, is an ultrasound-based diagnosis that also can arise without hypertension [3]. Pre-eclampsia is considered to be a heterogeneous disorder with different subtypes [4], variable clinical presentation, and a variable course of evolution, including maternal cardiovascular and placental dysfunction [5].

Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 4, 2024 Category: OBGYN Authors: Ida Catharina P üschl, Meera Thaneswaran Vyramuthu, Lisbeth Bonde, Morten Lebech, Hiba Iraqi Møller, Thomas Vauvert F. Hviid, Bjarke Lund Sørensen, Nicholas S. Macklon Tags: Full length article Source Type: research