Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort

ConclusionsThe current study is unable to fully replicate the autism-related brain patterns from LEAP in the ENIGMA cohort. The diverse group effects across ENIGMA sites demonstrate the challenges of generalizing the average findings of the GM covariation patterns to a large-scale cohort integrated retrospectively from multiple studies. Further analyses need to be conducted to gain additional insights into the generalizability of these two GM covariation patterns.

http://link.springer.com/10.1186/s13229-024-00583-8

Source: Molecular Autism - January 17, 2024 Category: Molecular Biology Source Type: research