Improved heart function and cardiac remodelling following sacubitril/valsartan in acute coronary syndrome with HF

ConclusionsThe cardiac function is improved and cardiac remodelling is reversed significantly after treatment of S/V in ACS patients with reduced left ventricular ejection fraction after PCI, and the improvement is more obvious than the routine group. There is a significant negative correlation between the change in LVEF and the changes in NT-proBNP, LVMI, LVEDVI, and LVESVI. The increase of LVEF and the decrease of LVEDVI and LVESVI are protective factors to improve the prognosis. Patients with myocardial infarction and reduced left ventricular ejection fraction might benefit more from the initiation of S/V as first-line heart failure treatment after PCI.

Source: ESC Heart Failure - January 16, 2024 Category: Cardiology Authors: Henan Liu, Yongkang Su, Jian Shen, Yang Jiao, Ying Li, Bing Liu, Xiaoling Hou, Qinhua Jin, Yundai Chen, Zhijun Sun, Qing Xi, Bin Feng, Zhenhong Fu Tags: Original Article Source Type: research