Anticancer platinum-drug delivered by mesenchymal stromal cells improves its activity on glioblastoma

ConclusionsThe major conclusions are that cell mediated drug delivery systems could provide a potential approach to facilitate the GBM therapy by intra-tumoral administration of cells loaded with Pt-8AQ, being MSCs able to integrate it into the tumor mass and exert high therapeutic efficacy in situ. The increased efficacy of Pt-8AQ delivered by MSCs even suggests to deeper investigate a possible direct use of MSCs secretome both in situ and/or by systemic administration, being secretome able to pass the blood –brain tumor.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research