Intratumor genetic heterogeneity and head and neck cancer relapse

Head and neck squamous cell carcinoma (HNSCC) develops in the epithelial cells of the mucosal lining of the upper aerodigestive tract. HNSCC is one of the more common cancers with approximately 900,000 new cases per year diagnosed worldwide [1,2]. Exogenous carcinogens such as tobacco and alcohol are the classic risk factors for HNSCC. More recently a persistent infection with the human papillomavirus (HPV) has been recognized as risk factor [3], particularly in oropharyngeal squamous cell carcinomas (OPSCC).

Source: Radiotherapy and Oncology - January 5, 2024 Category: Radiology Authors: A.S. Pierik, J.B. Poell, A. Brink, M. Stigter- van Walsum, R.H. de Roest, T. Poli, A. Yaromin, P. Lambin, C.R. Leemans, R.H. Brakenhoff Tags: Original Article Source Type: research