The mitochondriogenic but not the immunosuppressant effects of mTOR inhibitors prompt neuroprotection and delay disease evolution in a mouse model of progressive multiple sclerosis

DISCUSSION: Data corroborate the key role of mitochondriogenesis to treatment of MS progression, and for the first time disclose the translational potential of mTOR inhibitors in PMS therapy.PMID:38142841 | DOI:10.1016/j.nbd.2023.106387

Source: Neurobiology of Disease - December 24, 2023 Category: Neurology Authors: Daniela Buonvicino Sara Pratesi Giuseppe Ranieri Alessandra Pistolesi Daniele Guasti Alberto Chiarugi Source Type: research