Associations of infections and vaccines with Alzheimer's disease point to a major role of compromised immunity rather than specific pathogen in AD

DISCUSSION: Our results support the idea that the connection between AD and infections involves compromised immunity rather than specific pathogen. We discuss mechanisms by which the declining immune surveillance may promote AD, and the role of biological aging in it. Repurposing of vaccines with broad beneficial effects on immunity could be a reasonable approach to AD prevention. Pneumococcal and zoster vaccines are promising candidates for such repurposing.PMID:38106098 | PMC:PMC10723482 | DOI:10.1101/2023.12.04.23299092

Source: Herpes - December 18, 2023 Category: Infectious Diseases Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research