Unraveling the link between dietary factors and cardiovascular metabolic diseases: Insights from a two-sample Mendelian Randomization investigation

Dietary nutrition plays a dual role, serving as a vital energy source and a substantial modifiable risk factor. Unhealthy eating habits can worsen the burden of non-communicable diseases. Extensive research underscores the profound impact of dietary nutrition on the emergence of cardiovascular metabolic diseases, encompassing conditions like coronary artery disease (CAD), heart failure (HF), ischemic stroke (IS), and type 2 diabetes (T2DM).1 However, research findings are contradictory, as some studies demonstrate that dietary nutritional factors increase the risk of individuals developing diseases,2 while others show the opposite,3 This discrepancy may arise from the reliance on traditional observational studies, which are vulnerable to confounding factors and reverse causation,4 Consequently, the causal relationship between dietary factors and cardiovascular metabolic diseases remains unclear.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research