An Intestinal FXR Agonist Mitigates Dysbiosis, Intestinal Tight Junctions, and Inflammation in High ‐Fat Diet‐Fed Mice

ConclusionFEX stimulates intestinal FXR and improves dysbiosis, intestinal TJs, and the release of incretins, mitigating glucose intolerance and BM increases induced by an HF diet. However, FEX results in glucose intolerance, insulin resistance, and reduces intestinal TJs in a control group, thus demonstrating limitations to this dietary model.

Source: Molecular Nutrition and Food Research - December 12, 2023 Category: Food Science Authors: Tamiris Ingrid Petito ‐da‐Silva, Felipe Missiba Villardi Júnior, Aline Penna‐de‐Carvalho, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello, Sandra Barbosa‐da‐Silva Tags: Research Article Source Type: research