A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection

ConclusionThis study on a large cohort at risk of ZCL confirmed IFN- γ and GrB as protective factors against the disease. A high IFN-γ/IL-10 ratio, but not GrB/IL-10 ratio was associated with resistance. These results are valuable for developing and evaluating of a vaccine against human leishmaniasis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research