High expression of the glutathione S-transferase A2 and neuropilin-2 genes affects pancreatic islet β-cell function

ConclusionsThe results suggest that Nrp2 regulates apoptosis in Min6 cells and that there may be a link between this molecule and pathological apoptosis of pancreatic β-cells in T2DM patients. However, Gsta2 was not found to be an upstream regulator of Nrp2 in our cell line. Therefore, Gsta2 regulation of apoptosis in Min6 cells may be achieved through other apoptotic pathways.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research