Insulin resistance and metabolism-associated fatty liver disease: Pathways of action of hypoglycemic agents

Ann Hepatol. 2023 Nov 30:101182. doi: 10.1016/j.aohep.2023.101182. Online ahead of print.ABSTRACTMetabolism-associated fatty liver disease (MAFLD) is characterized by overweight/obesity, and the presence of type 2 diabetes mellitus is the most important criterion. We propose an independent disease perspective without exclusion criteria and with less heterogeneity and greater impact because, according to the National Health and Nutrition Survey (ENSANUT), in Mexico, 25% of adults over 60 years of age suffer from diabetes, and 96% of those over 50 years of age have abdominal obesity. Due to the impact of insulin resistance in the pathophysiology of MAFLD, which results in damage to hepatocytes, this work aims to provide an overview of the action pathways of hypoglycemic agents such as glucagon-like-1 receptor agonist and peroxisome proliferator-activated receptor-gamma agonists, whose importance lies in the fact that they are currently undergoing phase 2 studies, as well as dipeptidyl peptidase 4 inhibitors and sodium-glucose co-transporter type 2 inhibitors, which are undergoing phase 1 study trials.PMID:38042482 | DOI:10.1016/j.aohep.2023.101182
Source: Annals of Hepatology - Category: Gastroenterology Authors: Source Type: research