[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration

Conclusion: [18F]PI-2620 SUVr shows an intense and consistent signal in AD but lower-intensity, heterogeneous, and rapidly decreasing binding in patients with suspected FTLD. Further work is needed to delineate the substrate of [18F]PI-2620 binding and the usefulness of [18F]PI2620 SUVr quantification outside the AD continuum.

Source: Journal of Nuclear Medicine - December 1, 2023 Category: Nuclear Medicine Authors: Blazhenets, G., Soleimani-Meigooni, D. N., Thomas, W., Mundada, N., Brendel, M., Vento, S., VandeVrede, L., Heuer, H. W., Ljubenkov, P., Rojas, J. C., Chen, M. K., Amuiri, A. N., Miller, Z., Gorno-Tempini, M. L., Miller, B. L., Rosen, H. J., Litvan, I., G Tags: Clinical Investigations Source Type: research