Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling

ConclusionsOur findings suggest that stiff matrix induces expression of pro-metastatic and neurotrophic genes through integrin β1-FAK-YAP signals, which finally facilitates PNI in BRCA. Thus, our study provides a new mechanism for PNI in BRCA and highlights nerve-based tumor treatment strategies.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research