Cancers, Vol. 15, Pages 5569: Quality of Life and Independent Factors Associated with Poor Digestive Function after Ivor Lewis Esophagectomy

Cancers, Vol. 15, Pages 5569: Quality of Life and Independent Factors Associated with Poor Digestive Function after Ivor Lewis Esophagectomy Cancers doi: 10.3390/cancers15235569 Authors: Valerian Dirr Diana Vetter Thomas Sartoretti Marcel André Schneider Francesca Da Canal Christian A. Gutschow Transthoracic esophagectomy results in a radical change in foregut anatomy with multiple consequences for digestive physiology. The aim of this study was to identify factors associated with poor functional outcomes by assessing multiple dimensions of digestive performance and health-related quality of life (HRQL). Patients with cancer-free survival after Ivor Lewis esophagectomy were included. Four functional syndromes (dysphagia, gastroesophageal reflux disease (GERD), delayed gastric conduit emptying (DGCE), and dumping syndrome (DS)) and HRQL were assessed using specifically designed questionnaires. Patient outcomes were compared with healthy controls. Independent factors associated with poor digestive performance were identified through multivariable analysis. Sixty-five postoperative patients and 50 healthy volunteers participated in this study. Compared with controls, patients had worse outcomes for dysphagia, GERD, DS, and HRQL, but not for DGCE. A multivariate analysis showed a significant correlation of reduced digestive performance with ASA score, squamous cell carcinoma, open or hybrid surgical approach, and (neo)adjuvant therapy. In contrast, no individua...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research