Wireless transcutaneous electric nerve stimulation (TENS) for chronic chemotherapy-induced peripheral neuropathy (CIPN): a proof-of-concept randomized clinical trial

Chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 30%-60% of people who receive neurotoxic chemotherapy. CIPN is associated with impaired quality of life and function and has few effective treatments. This 6-site, subject and assessor blinded RCT was designed to assess (1) preliminary efficacy (i.e., alpha pre-specified at 0.2) of a wearable, app-controlled, TENS device for chronic CIPN and (2) feasibility of conducting a confirmatory trial within the NCI Community Oncology Research Program (NCORP) (NCT 04367480).

Source: The Journal of Pain - November 20, 2023 Category: Materials Science Authors: Jennifer S. Gewandter, Eva Culakova, Jenae N. Davis, Umang Gada, Joseph J. Guido, James D. Bearden, Brain Burnette, Dhaval Shah, Gary Morrow, Karen Mustian, Kathleen Sluka, Nimish Mohile Source Type: research