Haptoglobin gene polymorphism and iron profile in sickle cell disease patients with inflammation in Yaounde, Cameroon

ConclusionThis study demonstrates a higher frequency of genotypeHP 1-1 followed by theHP 2-2 genotype in patients with major sickle cell syndromes. However, a larger proportion of patients with genotypeHP 2-2 are associated with hematological profile disorders, inflammation, and dysregulation of iron metabolism. Then, the haptoglobin polymorphism contributes to the severity of major sickle cell syndromes.

Source: Molecular Genetics & Genomic Medicine - November 17, 2023 Category: Genetics & Stem Cells Authors: Romaric De Manfouo Tuono, Josu é Louokdom Simo, Prosper Cabral Biapa Nya, Jean Paul Chedjou, Christian Bernard Kengne Fotsing, Bernard Claude Chetcha, Calvino Fomboh Tah, Claude Tagny Tayou, Wilfried Fon Mbatcham, Constant Anatole Pieme Tags: ORIGINAL ARTICLE Source Type: research