O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis

ConclusionsOur findings identified a novel post-translational modification of GSDMD and elucidated theO-GlcNAcylation of GSDMD inhibits LPS-induced endothelial injury, suggesting thatO-GlcNAc modification-based treatments could serve as potential interventions for sepsis-associated vascular endothelial injury.
Source: Inflammation Research - Category: Research Source Type: research