Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice

CONCLUSION: This study has demonstrated that the plasma concentration of ATOR was potentiated in the presence of LACO, but not in the presence of LEVE and it has provided significant protection against both the electro and chemo-convulsive models in mice. This could be due to the symbiotic pharmacokinetic interplay of ATOR with LACO, and possibly, this interplay may interfere with sodium channel conductance.PMID:37921161 | DOI:10.2174/0113892002253895231020100743

Source: Epilepsy Curr - November 3, 2023 Category: Neurology Authors: Jayaraman Rajangam Arun Prasath Lakshmanan Narahari N Palei Karthikeyan Elumalai Muddukrishnaiah Kotakonda R Prakash P Latha Source Type: research